Willem Dafoe as Green Goblin
Alfred Molina as Doctor Octopus
Thomas Haden Church as Sandman
Topher Grace as Venom
Bruce Campbell as Mysterio
John Malkovich as Vulture
Dylan Baker as The Lizard
Oleg Taktarov as Rhino
Gerard Butler as Kraven the Hunter
Ben Foster as Electro
Christian Slater as Shocker
Arnold Vosloo as Scorpion
Peter Sarsgaard as Chameleon
Tony Todd as Tombstone
Oded Fehr as Morbius
John Travolta as Hammerhead
John Goodman as Kingpin
Anne Hathaway as Black Cat
Michael C. Hall as Hobgoblin
Jim Carrey as Carnage